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A9227

ABT-491 hydrochloride

≥98% (HPLC), active platelet-activating factor (PAF) receptor antagonist, solid

Synonym(s):

4-Ethynyl-N,N-dimethyl-3-[3-fluoro-4-[(2-methyl-1H-imidazo-[4,5-c]pyridin-1-yl)methyl]benzoyl]-1H-indole-1-carboxamide hydrochloride, A-137491

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About This Item

Empirical Formula (Hill Notation):
C28H22N5O2F · HCl
CAS Number:
189689-94-9
Molecular Weight:
515.97
UNSPSC Code:
12352200
PubChem Substance ID:
24724404
NACRES:
NA.77
MDL number:
MFCD00945301
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
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Product Name

ABT-491 hydrochloride, ≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

mp

170-178 °C (lit.)

solubility

H2O: freely soluble 22 mg/mL

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c5c(cccc15)C#C

InChI

1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H

InChI key

AWRGBOKANQBIBM-UHFFFAOYSA-N

Biochem/physiol Actions

Highly potent, selective and orally active platelet-activating factor (PAF) receptor antagonist. Ki = 0.6 nM in human platelets.

Features and Benefits

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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