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A9481

AD 198

Name: AD 198
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

N-Benzyladriamycin-14-valerate

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About This Item

Empirical Formula (Hill Notation):

C₃₉H₄₃NO₁₂

CAS Number:

98983-21-2

Molecular Weight:

717.76

UNSPSC Code:

12352200

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Properties

assay

≥98% (HPLC)

form

solid

color

red

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NCc3ccccc3)[C@H](O)[C@H](C)O2)c4c(O)c5C(=O)c6c(OC)cccc6C(=O)c5c(O)c4C1

Description

Biochem/physiol Actions

AD 198 is a PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme that plays a critical role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis.

AD 198 is a PKC-delta activator.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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