A9570
MilliShot® Amphotericin B Ready Made Solution
250 μg/mL in deionized water, 0.2 μm filtered, BioReagent, suitable for cell culture
Synonym(s):
Amphotericin, Fungizone
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About This Item
NACRES:
NA.76
biological source
yeast
Quality Segment
sterility
0.2 μm filtered
product line
BioReagent
form
liquid
shelf life
2 yr
storage condition
protect from light
technique(s)
cell culture | mammalian: suitable
shipped in
dry ice
storage temp.
-10 to -25°C
General description
Amphotericin B is a macrocyclic lactone with a hydrophilic polyhydroxyl chain and a lipophilic polyene based hydrocarbon chain
Application
Amphotericin B solution has been used:
- as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice
- as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries
- as a constituent of transport medium during the collection of equine corpora lutea
- as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line
Biochem/physiol Actions
Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. that is clinically used to treat systemic fungal infections. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules. Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses.
Legal Information
MILLISHOT is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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