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A9650

Angiotensin I human acetate salt hydrate

Name: Angiotensin I human acetate salt hydrate
Brand: SIGMA

≥90% (HPLC), powder, suitable for mammalian cell culture

Synonym(s):

5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I

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About This Item

Empirical Formula (Hill Notation):

C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O

CAS Number:

70937-97-2

Molecular Weight:

1296.48 (anhydrous free base basis)

UNSPSC Code:

12352202

eCl@ss:

42020611

PubChem Substance ID:

24891483

NACRES:

NA.32

MDL number:

MFCD00133091

Form:

powder

Assay:

≥90% (HPLC)

Biological source:

human

Mol wt:

1296 Da by calculation (Average Mass)

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Properties

biological source

human

Quality Level

200

assay

≥90% (HPLC)

form

powder

mol wt

1296 Da by calculation (Average Mass)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

cell culture | mammalian: suitable

solubility

acetic acid: 25 mg/mL, clear, colorless

UniProt accession no.

P01019

storage temp.

−20°C

SMILES string

CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1

InChI key

CKIFOTYDIFUKEP-AUVUXLIHSA-N

Gene Information

human ... AGT(183)

Description

General description

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Research area: Cell Signaling

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH₃COOH.6H₂O

Application

Angiotensin I human acetate salt hydrate has been used:

as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

Biochem/physiol Actions

Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Putative neurotransmitter; precursor of angiotensin II and of angiotensin fragment 1-7.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000512780

0000492067

0000463819

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Global Trade Item Number

SKU	GTIN
A9650-1MG	04061833412152
A9650-5MG	04061833412176
A9650-10MG	04061833412145
A9650-50MG	04061833412169