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A9736

A-438079 hydrochloride hydrate

Name: A-438079 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), P2X7 purinoceptor antagonist, powder

Synonym(s):

3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl pyridine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₉Cl₂N₅·HCl · xH₂O

CAS Number:

899431-18-6

Molecular Weight:

342.61 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329771058

NACRES:

NA.77

MDL number:

MFCD17215929

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

A-438079 hydrochloride hydrate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

originator

Abbott

storage temp.

2-8°C

SMILES string

O.Cl.Clc1cccc(c1Cl)-c2nnnn2Cc3cccnc3

InChI

1S/C13H9Cl2N5.ClH.H2O/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;;/h1-7H,8H2;1H;1H2

InChI key

ZHFJJBAKSROKNO-UHFFFAOYSA-N

Description

Application

A-438079 hydrochloride hydrate has been used to determine its inhibitory effect on purinergic receptors. It has also been used to check its inhibitory effects on macrophages.

Biochem/physiol Actions

A-438079 hydrochloride hydrate is a selective P2X7 purinoceptor antagonist

A-438079 hydrochloride hydrate is a selective P2X7 purinoceptor antagonist in both human and rat with minimal activity at 75 different G-protein-coupled receptors, enzymes, transporters, and ion channels tested.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c