Key Documents

View All Documentation

A9810

Amyloid β Protein Fragment 1-42

Name: Amyloid β Protein Fragment 1-42
Brand: SIGMA

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₀₃H₃₁₁N₅₅O₆₀S

CAS Number:

107761-42-2

Molecular Weight:

4514.04

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00163049

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

assay

≥95% (HPLC)

Quality Level

200

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(

InChI

1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112

InChI key

DZHSAHHDTRWUTF-SIQRNXPUSA-N

Gene Information

human ... APP(351)

General description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Application

Amyloid β Protein Fragment 1-42 has been used:

for the preparation of Aβ 1-42 oligomer
for western blot analysis
for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay
to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity
to investigate the effect of Aβ in epithelial cell culture

Biochem/physiol Actions

Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.

The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Plasma Amyloid-beta(Abeta 42) Correlates with Cerebrospinal Fluid Abeta 42 in Alzheimer?s Disease

Teunissen CE, et al.

Journal of Alzheimer'S Disease, 1-7 (2018)

Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor alpha and the Activity of gamma-secretase in a beta-amyloid Protein-dependent Mechanism in APP/PS1 Transgenic Mice

Yu X, et al.

Frontiers in Molecular Neuroscience, 11 (2018)

The role of Abeta circRNA in Alzheimer? s disease: alternative mechanism of Abeta biogenesis from Abeta circRNA translation

Mo D, et al.

bioRxiv, 260968-260968 (2018)

Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease.

Kyunghee Byun et al.

PloS one, 7(5), e37917-e37917 (2012-06-05)

Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we demonstrate that AGE-albumin, the most abundant AGE product in human

Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity

Yao ZX and Papadopoulos V

Faseb Journal, 16(12), 1677-1679 (2002)

View All Related Papers

Global Trade Item Number

SKU	GTIN
A9810-.1MG	04061835553754

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service