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A9899

Antazoline hydrochloride

Name: Antazoline hydrochloride
Brand: SIGMA

Synonym(s):

2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉N₃ · HCl

CAS Number:

2508-72-7

Molecular Weight:

301.81

NACRES:

NA.77

PubChem Substance ID:

24277763

UNSPSC Code:

12352200

EC Number:

219-719-8

MDL number:

MFCD00058145

Form:

powder

Quality level:

200

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form

powder

Quality Level

200

originator

Novartis

SMILES string

Cl.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1

InChI

1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H

InChI key

SWKDMSRRIBZZAY-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Biochem/physiol Actions

Imidazoline agonist; H₁ histamine receptor antagonist.

Imidazoline agonist; more potent than efaroxan in inducing insulin release from β cells; H₁ histamine receptor antagonist.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H315,H319,H335

pcodes

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor.

G Olmos et al.

British journal of pharmacology, 127(6), 1317-1326 (1999-08-24)

This study was designed to assess the potential neuroprotective effect of several imidazol(ine) drugs and agmatine on glutamate-induced necrosis and on apoptosis induced by low extracellular K+ in cultured cerebellar granule cells. Exposure (30 min) of energy deprived cells to

Synthesis and identification of the primary degradation product in a commercial ophthalmic formulation using NMR, MS, and a stability-indicating HPLC method for antazoline and naphazoline.

S C Ruckmick et al.

Journal of pharmaceutical sciences, 84(4), 502-507 (1995-04-01)

HPLC analysis of an anti-infective ophthalmic solution (Albalon-A), containing the active drugs naphazoline and antazoline, revealed a degradation peak of unknown identity. To elucidate the identity of the degradant, the active drugs were each hydrolyzed by refluxing at high pH

Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas.

D Berdeu et al.

European journal of pharmacology, 254(1-2), 119-125 (1994-03-11)

The effects of imidazolines and derivatives were studied on insulin secretion and vascular resistance in the isolated perfused rat pancreas. On insulin secretion, two imidazoline alpha 2-adrenoceptor antagonists, efaroxan (1-100 microM) and RX821002 (10 microM), had a stimulating response; however

Influence of antazoline and ketotifen on the anticonvulsant activity of conventional antiepileptics against maximal electroshock in mice.

Mariusz Swiader et al.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14(4), 307-318 (2004-05-28)

Experimental studies have indicated that the central histaminergic system plays an important role in the inhibition of seizures through the stimulation of histamine H1 receptors. H1 receptor antagonists, including classical antiallergic drugs, occasionally may induce convulsions in healthy children and

Demand for food and cocaine in Fischer and Lewis rats.

Chesley J Christensen et al.

Behavioral neuroscience, 123(1), 165-171 (2009-01-28)

Fischer and Lewis rat strains often serve as animal vulnerability models for drug abuse and addiction. When these strains respond for drugs of abuse, several measures, including total drug intake, response rate and progressive-ratio breakpoints, have been reported to be

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Global Trade Item Number

SKU	GTIN
A9899-25G	04061832088778

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