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Merck
CN

A9965

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin

≥95% (HPLC), powder

Synonym(s):

Ac-YVAD-AFC

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About This Item

Linear Formula:
C33H36N5O10F3
Molecular Weight:
719.66
NACRES:
NA.32
PubChem Substance ID:
329771064
UNSPSC Code:
12352209
MDL number:
MFCD01318881

Key Documents

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Product Name

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin, ≥95% (HPLC), powder

InChI

1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1

SMILES string

CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI key

GWKJISJKNKIJNP-DEQDFGQZSA-N

assay

≥95% (HPLC)

form

powder

color

white

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CASP1(834), CASP4(837)
mouse ... CASP1(12362), CASP4(12363)
rat ... CASP1(25166), CASP4(114555)

General description

Membrane-permeable fluorogenic substrate for caspase 1 (ICE) and caspase 4 (TX).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCH1994
SLCG9798
SLCG2758
SLCF9769
SLCD4386

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Emma M Creagh et al.
PloS one, 4(3), e5055-e5055 (2009-03-31)
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R A Jones et al.
Hepatology (Baltimore, Md.), 27(6), 1632-1642 (1998-06-10)
The mechanism of Fas antigen-induced hepatocyte apoptosis was investigated. Using a monoclonal antibody directed against the Fas antigen, apoptosis was induced in freshly isolated murine hepatocytes within 90 minutes of antibody addition as assessed by plasma membrane bleb formation, chromatin
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The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the
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