AC-0351A
Claudin-1 (EP420) Rabbit Monoclonal Primary Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
monoclonal
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
Application:
IHC (p)
Citations:
-
biological source
rabbit
antibody form
Ig fraction of antiserum
clone
monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
shipped in
wet ice
storage temp.
2-8°C
visualization
(membrane/cytoplasm)
General description
Claudin-1 (CLDN-1) is a member of the claudin integral membrane tight junction protein family. Claudins are responsible for regulating paracellular permeability, promoting cell adhesion and maintaining cell polarity and barrier function. Localized to the cytosol and membrane, Claudin-1 is broadly expressed in most tissues and is localized to most epithelial cells. Surrounding secretory epithelial cells of stroma components such as fibroblasts, pneumocytes and lymphocytes do not express Claudin-1. Claudin-1 expression is typically reduced in proliferating compared to quiescent epithelial cells. Claudin-1 was immuno-negative in 98% of prostate cancer cases and significantly decreased in colon carcinoma tissue compared to adjacent normal mucosa. Furthermore, Claudin-1 has demonstrated utility for identifying squamous cell carcinomas (SqCC). In lung tumors, Claudin-1 expression was detected in 78% of SqCC but only 17% of adenocarcinoma. Its upregulation is observed in pancreatic, thyroid, lung and oral SqCC.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For a copy of the IFU and CofA contact IVDorder@ABCAM.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
监管及禁止进口产品
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