AV31592
Anti-AEBP1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-AE binding protein 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
131 kDa
species reactivity
rabbit, horse, guinea pig, rat, human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AEBP1(165)
General description
AEBP1 is a transcriptional repressor that negatively regulates PTEN. This transcription factor is involved in adipocyte growth and is a sex-specific risk factor for diet-induced obesity. Furthermore, AEBP1 is also known to have proinflammatory roles in macrophages.
Rabbit Anti-AEBP1 antibody recognizes human, mouse, rat, and pig AEBP1.
The previously assigned protein identifier Q14113 has been merged into Q8IUX7. Full details can be found on the UniProt database.
Rabbit Anti-AEBP1 antibody recognizes human, mouse, rat, and pig AEBP1.
The previously assigned protein identifier Q14113 has been merged into Q8IUX7. Full details can be found on the UniProt database.
Immunogen
Synthetic peptide directed towards the N terminal region of human AEBP1
Application
Rabbit Anti-AEBP1 antibody can be used for immunohistochemical assays at concentration of 4-8μg/ml. It can also be used for western blot (0.2-5.0μg/ml) applications.
Biochem/physiol Actions
The adipocyte enhancer binding protein 1 (AEBP1) is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. AEBP1 may play a role in differentiated vascular smooth muscle cells.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: VPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEK
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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常规特殊物品
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Amin Majdalawieh et al.
Mediators of inflammation, 2010, 823821-823821 (2010-04-17)
NF-kappaB comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-kappaB in inflammation and atherosclerosis and the regulation of the NF-kappaB signaling pathway are summarized. The structure, function, and
Lei Zhang et al.
Molecular medicine (Cambridge, Mass.), 11(1-12), 39-47 (2005-11-25)
Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP1, which functions as a negative regulator of PTEN through a protein-protein interaction, is highly
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