AV35098
Anti-KCNN4 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-KCA4, Anti-KCa3.1, Anti-IK1, Anti-IKCA1, Anti-SK4, Anti-Small conductance calcium-activated channel, subfamily N, member 4, Anti-hIKCa1, Anti-hKCa4
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-KCNN4 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
48 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNN4(3783)
Application
Anti-KCNN4 antibody produced in rabbit has been used in:
- western blot analysis
- immunofluorescence
- staining
- immunohistochemistry
Biochem/physiol Actions
KCNN4 (potassium calcium-activated channel subfamily N member 4) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, KCNN4, is a component of a potassium channel activated by calcium. It is critically involved in calcium ion transport and cell homeostasis.
Immunogen
Synthetic peptide directed towards the C terminal region of human KCNN4
Other Notes
Synthetic peptide located within the following region: DLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3. 1 and ClC-3
Cuddapah VA, et al.
The Journal of Neuroscience, 33(4), 1427-1440 (2013)
Javier Lozano-Gerona et al.
PloS one, 15(3), e0222619-e0222619 (2020-03-10)
Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca2+-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KCa3.1+-transgene under the
D Strøbæk et al.
British journal of pharmacology, 168(2), 432-444 (2012-08-16)
The K(Ca) 3.1 channel is a potential target for therapy of immune disease. We identified a compound from a new chemical class of K(Ca) 3.1 inhibitors and assessed in vitro and in vivo inhibition of immune responses. We characterized the
A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes
Logsdon NJ, et al.
The Journal of Biological Chemistry, 272(52), 32723-32726 (1997)
Epigenetic dysregulation of KCa3. 1 channels induces poor prognosis in lung cancer
Bulk E, et al.
International Journal of Cancer. Journal International Du Cancer, 137(6), 1306-1317 (2015)
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