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Merck
CN

AV35122

Anti-VDAC1 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Voltage-dependent anion channel 1

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About This Item

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
4

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

31 kDa

species reactivity

zebrafish, pig, canine, horse, guinea pig, rabbit, bovine, human, mouse, sheep, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_003365

UniProt accession no.

P21796

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VDAC1(7416)

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General description

VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules.

Immunogen

The immunogen for anti-VDAC1 antibody: synthetic peptide derected towards the C terminal of human VDAC1

Application

Muscle whole-cell extracts from mice were subjected to western blot analysis using rabbit anti-vdac as the primary antibody at a 1:2000 dilution.

Physical form

Lyophilized from PBS buffer with 2% sucrose

Other Notes

Synthetic peptide located within the following region: SAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC4487

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Sebastian Hiller et al.
Trends in biochemical sciences, 35(9), 514-521 (2010-08-17)
The most abundant protein of the mitochondrial outer membrane is the voltage-dependent anion channel (VDAC), which facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by interactions with other proteins and small molecules. VDAC has
Julio E Ayala et al.
Diabetes, 56(4), 1025-1033 (2007-01-19)
Stimulation of nitric oxide-cGMP signaling results in vascular relaxation and increased muscle glucose uptake. We show that chronically inhibiting cGMP hydrolysis with the phosphodiesterase-5 inhibitor sildenafil improves energy balance and enhances in vivo insulin action in a mouse model of
Mia Ydfors et al.
The Journal of physiology, 594(11), 3127-3140 (2015-12-04)
Mitochondrial respiratory sensitivity to ADP is thought to influence muscle fitness and is partly regulated by cytosolic-mitochondrial diffusion of ADP or phosphate shuttling via creatine/phosphocreatine (Cr/PCr) through mitochondrial creatine kinase (mtCK). Previous measurements of respiration in vitro with Cr (saturate
Claudio Asencio et al.
European journal of human genetics : EJHG, 24(3), 367-372 (2015-05-28)
Coenzyme Q10 (CoQ10) deficiency is associated to a variety of clinical phenotypes including neuromuscular and nephrotic disorders. We report two unrelated boys presenting encephalopathy, ataxia, and lactic acidosis, who died with necrotic lesions in different areas of brain. Levels of

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