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Merck
CN

AV35766

Sigma-Aldrich

Anti-HMGB3 (AB2) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-High-mobility group box 3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

23 kDa

species reactivity

horse, mouse, human, rat, bovine, guinea pig, dog, rabbit

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_005333

UniProt accession no.

O15347

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HMGB3(3149)

Immunogen

Synthetic peptide directed towards the C terminal region of human HMGB3

Biochem/physiol Actions

HMGB3 belongs to high mobility group of proteins and contains HMG box domain that binds DNA. It plays a critical role in DNA replication, nucleosome assembly and transcription. HMGB3 reportedly regulates cell proliferation, migration and invasion of B cells and gastric cancer cells.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: NLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEE

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
QC5111

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Michael J Nemeth et al.
Blood, 102(4), 1298-1306 (2003-04-26)
Hmgb3 is a member of a family of chromatin-binding proteins that can alter DNA structure to facilitate transcription factor binding. We identified the Hmgb3 cDNA in a subtractive hybridization screen for transcripts that are preferentially expressed in hematopoietic stem cells.
Y Gong et al.
Genetics and molecular research : GMR, 12(4), 6032-6039 (2013-12-18)
Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has

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