AV38701
Anti-MEOX2 (AB3) antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-Mesenchyme homeobox 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
33 kDa
species reactivity
rabbit, guinea pig, bovine, horse, human, dog
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MEOX2(4223)
Immunogen
Synthetic peptide directed towards the C terminal region of human MEOX2
Biochem/physiol Actions
MEOX2 is a transcription regulator that is essential for limb myogenesis in vertebrates. It regulates the activity of NF-κB and inhibits the activation of vascular endothelial cells in response to hypoxia and proangiogenic factors. MEOX1 and 2 regulate the activity cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) and induce cell cycle arrest in endothelial cells.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: REKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Susan Reijntjes et al.
The International journal of developmental biology, 51(8), 753-759 (2007-10-17)
We have examined the expression pattern of the avian Meox1 homeobox gene during early development and up to late limb bud stages. Its expression pattern indicates that it is involved in somite specification and differentiation. The domains of expression are
Yun Chen et al.
Cardiovascular research, 87(4), 723-731 (2010-04-28)
Tumours secrete proangiogenic factors to induce the ingrowth of blood vessels, the end targets of which are vascular endothelial cells (ECs). The MEOX2 homeoprotein inhibits nuclear factor-kappaB (NF-kappaB) signalling and EC activation in response to serum and proangiogenic factors. We
Josette M Douville et al.
PloS one, 6(12), e29099-e29099 (2011-12-30)
Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are essential for determining whether a cell enters
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