AV39769
Anti-CREB3L1 (AB2) antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-cAMP responsive element binding protein 3-like 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
57 kDa
species reactivity
rabbit, mouse, bovine, rat, guinea pig, human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CREB3L1(90993)
General description
CREB3L1 (OASIS) is a transcription factor that is involved in the regulation of endoplasmic reticulum (ER) stress. It activates extracellular matrix gene expression and may play a role in the development of pancreas. CREB3L1 modulates the expression of the vasopressin gene in the hypothalamus of rats. EWSR1-CREB3L1 fusion transcript has been implicated in small cell osteosarcoma.
Rabbit Anti-CREB3L1 antibody recognizes bovine, human, mouse, rat, and canine CREB3L1.
Rabbit Anti-CREB3L1 antibody recognizes bovine, human, mouse, rat, and canine CREB3L1.
Immunogen
Synthetic peptide directed towards the N terminal region of human CREB3L1
Application
Rabbit Anti-CREB3L1 antibody is suitable for western blot applications at a concentration of 1.25 μg/ml.
Biochem/physiol Actions
The CREB3L1 gene encodes a protein with a transmembrane domain that is a transcriptional activator of the CREB/ATF family.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDF
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Mingkwan Greenwood et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(11), 3810-3820 (2014-03-14)
Arginine vasopressin (AVP) is a neurohypophysial hormone regulating hydromineral homeostasis. Here we show that the mRNA encoding cAMP responsive element-binding protein-3 like-1 (CREB3L1), a transcription factor of the CREB/activating transcription factor (ATF) family, increases in expression in parallel with AVP
Ravi N Vellanki et al.
Endocrinology, 151(9), 4146-4157 (2010-07-30)
Old astrocyte specifically induced substance (OASIS) has previously been shown to be a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation that is similar to ATF6. In this study we investigated the expression and activation
Larisa V Debelenko et al.
Genes, chromosomes & cancer, 50(12), 1054-1062 (2011-10-12)
Cellular morphology of small cell osteosarcoma, an aggressive variant of osteosarcoma, is similar to Ewing sarcoma, but its molecular pathogenesis is largely unknown. We report the case of a 12-year-old girl with multifocal small cell osteosarcoma positive for the Ewing
Yan Fan et al.
The Journal of biological chemistry, 291(43), 22819-22829 (2016-09-10)
HIV-1 Tat is a major culprit for HIV/neuroAIDS. One of the consistent hallmarks of HIV/neuroAIDS is reactive astrocytes or astrocytosis, characterized by increased cytoplasmic accumulation of the intermediate filament glial fibrillary acidic protein (GFAP). We have shown that that Tat
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