AV45322
Anti-OLR1 antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-CLEC8A, Anti-LOX1, Anti-Oxidized low density lipoprotein (lectin-like) receptor 1, Anti-SCARE1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
20 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... OLR1(4973)
Immunogen
Synthetic peptide directed towards the N terminal region of human OLR1
Application
Anti-OLR1 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.
Biochem/physiol Actions
Oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1; LOX1) is a receptor for low density lipoprotein (LDL) that belongs to C-type lectin superfamily. It binds, internalizes and degrades oxidized LDL and has a role as scavenger receptor. It may be involved in the regulation of Fas-induced apoptosis. Mutations in OLR1 gene are associated with atherosclerosis and myocardial infarction.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: QANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQ
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Angela Pirillo et al.
Mediators of inflammation, 2013, 152786-152786 (2013-08-13)
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on
Zufeng Ding et al.
Scientific reports, 3, 2091-2091 (2013-06-29)
Here we demonstrate that "concentration polarization" of ox-LDL enhances LOX-1 expression and ox-LDL uptake. It damages cell surface heparan sulfate proteoglycans (HSPG) and activates LOX-1 dependent autophagy and apoptosis. We also show that ox-LDL concentration polarization occurs on the surface
Miyuki Kumano-Kuramochi et al.
Biochemical and biophysical research communications, 434(3), 594-599 (2013-04-16)
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1.
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