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Merck
CN

AV46493

Anti-CCPG1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CPR8, Anti-Cell cycle progression 1, Anti-KIAA1254

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
Species reactivity:
human
Citations:
1
Technique(s):
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
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Product Name

Anti-CCPG1 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

87 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... CCPG1(9236)

Biochem/physiol Actions

CCPG1 acts as an assembly platform for Rho protein signaling complexes. It limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. It does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. It may be involved in cell cycle regulation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Synthetic peptide directed towards the middle region of human CCPG1

Other Notes

Synthetic peptide located within the following region: TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKE

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Zhanhui Wang et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1403-1415 (2014-08-08)
The molecular cochaperone CDC37 regulates the activities of multiple protein kinases, and is an attractive broad-spectrum target in many types of cancers in which it is over-expressed. This study investigates the antitumour effects of inhibiting CDC37 in human hepatocellular carcinoma

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