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Merck
CN

AV48346

Sigma-Aldrich

Anti-GADD45B antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZP566B133, Anti-GADD45BETA, Anti-Growth arrest and DNA-damage-inducible, β, Anti-MYD118

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

18 kDa

species reactivity

guinea pig, human, bovine, mouse, horse, canine, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_056490

UniProt accession no.

O75293

storage temp.

−20°C

Gene Information

human ... GADD45B(4616)

General description

Growth arrest and DNA-damage-inducible, β (GADD45B) regulates DNA demethylation, adult neurogenesis, p38 signaling and cellular apoptosis. Genetic defects or lack of GADD45B are known to affect long-term memory and synaptic plasticity.
Rabbit Anti-GADD45B antibody recognizes bovine, human, mouse, rat, and canine GADD45B.

Immunogen

The immunogen for anti-GADD45B antibody: synthetic peptide derected towards the middle region of human GADD45B

Application

Rabbit Anti-GADD45B antibody is suitable for western blot applications at a concentration of 0.25 μg/ml.

Physical form

Lyophilized from PBS buffer with 2% sucrose

Other Notes

Synthetic peptide located within the following region: FCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDAW

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC18746

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Faraz A Sultan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(48), 17059-17066 (2012-12-01)
Dynamic epigenetic mechanisms including histone and DNA modifications regulate animal behavior and memory. While numerous enzymes regulating these mechanisms have been linked to memory formation, the regulation of active DNA demethylation (i.e., cytosine-5 demethylation) has only recently been investigated. New
Xinheng Zhang et al.
Oncotarget, 7(42), 68883-68893 (2016-09-23)
Avian leukosis virus subgroup J (ALV-J) is a retroviruses that induces neoplasia, hepatomegaly, immunosuppression and poor performance in chickens. The tumorigenic and pathogenic mechanisms of ALV-J remain a hot topic. To explore anti-tumor genes that promote resistance to ALV-J infection
Dengke K Ma et al.
Science (New York, N.Y.), 323(5917), 1074-1077 (2009-01-03)
The mammalian brain exhibits diverse types of neural plasticity, including activity-dependent neurogenesis in the adult hippocampus. How transient activation of mature neurons leads to long-lasting modulation of adult neurogenesis is unknown. Here we identify Gadd45b as a neural activity-induced immediate
Da-Liang Ou et al.
Cancer research, 70(22), 9309-9318 (2010-11-11)
Markers that could accurately predict responses to the general kinase inhibitor sorafenib are needed to better leverage its clinical applications. In this study, we examined a hypothesized role in the drug response for the growth arrest DNA damage-inducible gene 45β
Prescott T Leach et al.
Learning & memory (Cold Spring Harbor, N.Y.), 19(8), 319-324 (2012-07-18)
Growth arrest and DNA damage-inducible β (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes. Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits. Furthermore
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