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Merck
CN

AV51632

Anti-MBNL2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZp781H1296, Anti-MBLL, Anti-MBLL39, Anti-MGC120625, Anti-MGC120626, Anti-MGC120628, Anti-Muscleblind-like 2 (Drosophila), Anti-PRO2032

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

28 kDa

species reactivity

rabbit, rat, bovine, dog, guinea pig, human, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_659002

UniProt accession no.

O95205

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MBNL2(10150)

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Immunogen

Synthetic peptide directed towards the middle region of human MBNL2

Application

Anti-MBNL2 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5 μg/ml.

Biochem/physiol Actions

Muscleblind-like splicing regulator 2 (MBNL2) is a C3H-type zinc finger protein that modulates the alternate splicing of pre-mRNA molecules. MBNL2-mediated splicing program is essential in the developing brain. The dysregulation of MBNL2 splicing activity results in myotonic dystrophy.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: ENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAA

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC21270

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Konstantinos Charizanis et al.
Neuron, 75(3), 437-450 (2012-08-14)
The RNA-mediated disease model for myotonic dystrophy (DM) proposes that microsatellite C(C)TG expansions express toxic RNAs that disrupt splicing regulation by altering MBNL1 and CELF1 activities. While this model explains DM manifestations in muscle, less is known about the effects
Ian Holt et al.
The American journal of pathology, 174(1), 216-227 (2008-12-20)
In myotonic dystrophy, muscleblind-like protein 1 (MBNL1) protein binds specifically to expanded CUG or CCUG repeats, which accumulate as discrete nuclear foci, and this is thought to prevent its function in the regulation of alternative splicing of pre-mRNAs. There is

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