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B003

Chloroethylclonidine dihydrochloride

solid

Synonym(s):

2-[2,6-Dichloro(N-β-chloroethyl-N-methyl)-4-aminomethyl]phenylimino-2-imidazolidine dihydrochloride, CEC dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H17Cl3N4 · 2HCl
CAS Number:
70107-07-2
Molecular Weight:
408.58
NACRES:
NA.32
PubChem Substance ID:
24278281
UNSPSC Code:
12352202
MDL number:
MFCD00055181
Form:
solid
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form

solid

color

off-white

solubility

0.1 M NaOH: 1 mg/mL (Stable for 24 hours at 4 °C.), H2O: 12 mg/mL (Stable for 24 hours at 4 °C.), methanol: 17 mg/mL (Stable for 24 hours at 4 °C.), aqueous base: unstable

SMILES string

Cl.Cl.CN(CCCl)Cc1cc(Cl)c(\N=C2/NCCN2)c(Cl)c1

InChI

1S/C13H17Cl3N4.2ClH/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13;;/h6-7H,2-5,8H2,1H3,(H2,17,18,19);2*1H

InChI key

CZSAXNDACBPMAB-UHFFFAOYSA-N

Gene Information

human ... ADRA1B(147)

Biochem/physiol Actions

Irreversible α1B-adrenoceptor alkylating agent.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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G Leclerc et al.
British journal of pharmacology, 71(1), 5-9 (1980-01-01)
1 alpha-Adrenoceptor stimulant activity was determined for noradrenaline (NA), clonidine and a series of para-substituted derivatives of clonidine on rat aortic strips, a rat brain synaptosome preparation, and anaesthetized pithed rats. The effects on the blood pressure of intraventricular (i.c.v.)
L Xiao et al.
European journal of pharmacology, 347(2-3), 319-327 (1998-07-08)
We quantified and compared the rates at which chloroethylclonidine (CEC) inactivated cloned rat alpha1A, alpha1B-, and alpha1D-adrenoceptors. Membranes from cells transfected with one of the three cloned alpha1-adrenoceptors were incubated for various intervals with 100 microM chloroethylclonidine at 10 degrees
M Takanashi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 343(6), 669-673 (1991-06-01)
The influence of the alpha 1b-adrenoceptor-selective antagonist chlorethylclonidine on the alpha 1-adrenergic positive inotropic effect and the phosphoinositide hydrolysis induced by phenylephrine was investigated in the rabbit ventricular myocardium. Pretreatment of membrane fractions derived from the rabbit ventricular muscle with
View All Related Papers

Global Trade Item Number

SKUGTIN
B003-25MG04061833002056
B003-10MG04061833002049
B003-100MG04061832269207