B013
N-(2-Chloroethyl)-N-ethyl-2-methylbenzylamine hydrochloride
solid
Synonym(s):
2-CEA, N-Ethyl-N-(2-chloroethyl)-2-methylbenzylamine hydrochloride, Xylamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H18ClN · HCl
CAS Number:
Molecular Weight:
248.19
UNSPSC Code:
12352103
MDL number:
form
solid
color
white
solubility
H2O: soluble, ethanol: soluble, methanol: soluble
SMILES string
Cl.CCN(CCCl)Cc1ccccc1C
Biochem/physiol Actions
Selective, irreversible blocker of norepinephrine transport into central and peripheral neurons.
Regulatory Information
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Y Huang
European journal of pharmacology, 327(1), 41-47 (1997-05-26)
The effects of noradrenaline uptake inhibitors on contractions evoked by electric field stimulation, noradrenaline, clonidine. 5-hydroxytryptamine, ATP, high K+, and BaCl2 in the epididymal half of rat isolated vas deferens were examined. Protriptyline, amitriptyline and xylamine concentration-dependently inhibited monophasic contractions
R W Ransom et al.
Life sciences, 37(13), 1177-1182 (1985-09-30)
Xylamine (XYL) administered to intact rats caused a 70-80% reduction in norepinephrine (NE) uptake by the vas deferens but had little or no effect on NE content in that tissue. The vas deferens accumulates 3H-XYL in vitro by a desmethylimipramine
T K Chang et al.
Brain research, 597(1), 162-165 (1992-11-27)
Primary astrocyte cultures from neonatal rat brains show a Na+-dependent, desipramine-sensitive uptake of [3H]norepinephrine ([3H]NE). Xylamine, a nitrogen mustard, attenuated this uptake of [3H]NE into the astrocytes (IC50 = 0.8 microM). The dose-dependent reduction of [3H]NE uptake by xylamine indicated