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B019

Phenoxybenzamine hydrochloride

Name: Phenoxybenzamine hydrochloride
Brand: SIGMA

≥97%, powder

Synonym(s):

N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₂ClNO · HCl

CAS Number:

63-92-3

Molecular Weight:

340.29

NACRES:

NA.77

PubChem Substance ID:

24277760

UNSPSC Code:

12352116

EC Number:

200-569-7

MDL number:

MFCD00055152

Assay:

≥97%

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥97%

form

powder

color

white

solubility

H₂O: slightly soluble, alcohol: soluble, propylene glycol: soluble

originator

Wellspring

storage temp.

2-8°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H351

pcodes

P201 - P301 + P312 + P330 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Standardized management improves outcomes after the Norwood procedure.

Chandra Srinivasan et al.

Congenital heart disease, 4(5), 329-337 (2009-09-11)

In the past decade, many advances in the care of patients undergoing the Norwood procedure (NP) have been reported, but management remains nonstandardized at many institutions. We studied the impact of a standardized management protocol for neonates undergoing NP. Care

Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration.

David J Unett et al.

The Journal of pharmacology and experimental therapeutics, 347(3), 645-659 (2013-09-21)

The kinetics of drug-receptor interactions can profoundly influence in vivo and in vitro pharmacology. In vitro, the potencies of slowly associating agonists may be underestimated in assays capturing transient signaling events. When divergent receptor-mediated signaling pathways are evaluated using combinations

Pheochromocytoma crisis is not a surgical emergency.

Anouk Scholten et al.

The Journal of clinical endocrinology and metabolism, 98(2), 581-591 (2013-01-04)

Pheochromocytoma crisis is a feared and potentially lethal complication of pheochromocytoma. We sought to determine the best treatment strategy for pheochromocytoma crisis patients and hypothesized that emergency resection is not indicated. Retrospective cohort study (1993-2011); literature review (1944-2011). Tertiary referral

In vivo evidence for the generation of a glucocorticoid receptor-heat shock protein-90 complex incapable of binding hormone by the calmodulin antagonist phenoxybenzamine.

Y M Ning et al.

Molecular endocrinology (Baltimore, Md.), 10(1), 14-23 (1996-01-01)

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor whose ability to bind hormone is thought to be dependent on association with the 90-kDa heat shock protein (hsp90). In the present study, we have generated a novel form of the

Is dexmedetomidine the agent of choice in the resection of pheochromocytoma?

Harsha V Polavarapu et al.

The American surgeon, 78(3), E127-E128 (2012-04-25)

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Global Trade Item Number

SKU	GTIN
B019-250MG	04061833419571

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