B1059
Bcl-w (Minus C-Terminus) human
>95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution
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About This Item
Form:
buffered aqueous glycerol solution
Assay:
>95% (SDS-PAGE)
Recombinant:
expressed in E. coli
Mol wt:
18 kDa by SDS-PAGE
Quality Segment
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
18 kDa by SDS-PAGE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BCL2L2(599)
General description
Lacks the mitochondrial targeting sequence but maintains the ability to neutralize pro-apoptotic Bcl-2 family members.
This recombinant Bcl-w lacks the mitochondrial targeting sequence but maintains the ability to neutralize pro-apoptotic Bcl-2 family members.
Biochem/physiol Actions
Anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol; promotes cell survival.
Like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Bcl-w is an anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol. It is required for normal sperm maturation. Natural Bcl-w contains a C-terminal mitochondrial targeting sequence.
Physical form
Supplied as a 0.2 μm filtered solution in 25 mM HEPES, pH 7.5, 0.1 M KCl, and 10% glycerol.
Analysis Note
Measured by its ability to inhibit caspase-8-cleaved human BID-mediated release of cytochrome c from isolated mouse liver mitochondria using ELISA.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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