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B134

BMY 7378 dihydrochloride

Name: BMY 7378 dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₃₁N₃O₃ · 2HCl

CAS Number:

21102-95-4

Molecular Weight:

458.42

NACRES:

NA.77

PubChem Substance ID:

24278080

UNSPSC Code:

12352200

MDL number:

MFCD00153771

Assay:

≥98% (HPLC)

Form:

solid

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Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: >5 mg/mL

SMILES string

Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O

InChI

1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H

InChI key

NIBOMXUDFLRHRV-UHFFFAOYSA-N

Gene Information

human ... ADRA1D(146), HTR1A(3350)

Description

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT_1A serotonin receptor agonist and selective α_1D-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bristol Myers Squibb Corporation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Global Trade Item Number

SKU	GTIN
B134-25MG	04061833422175
B134-100MG	04061833422168