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Merck
CN

B1502

Brain Extract from bovine brain

Type I, Folch Fraction I

Synonym(s):

Brain Extract from Bovine

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352211
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Product Name

Brain Extract from bovine brain, Type I, Folch Fraction I

biological source

bovine brain

type

Type I

form

powder

lipid type

phosphoglycerides

storage temp.

−20°C

Quality Level

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Application

Brain Extract from bovine brain has been used:
  • to prepare small unilamellar vesicles
  • in lipid binding assay
  • to aid the recovery of phosphoinositides and also to terminate the reaction in phosphatidylinositol 5-phosphate (PtdIns5P) and PtdIns4P assay
  • in liposome and protein self-aggregation assays

Biochem/physiol Actions

Brain lipids are involved in cellular signal transduction, membrane organization, trafficking protein modification, interactions and energy storage.

General description

Brain extract has lipids, especially polyunsaturated fatty acids (PUFAs) at high level. Extract from substantia niagra and the striatum has high amount of iron.

Other Notes

Contains phosphatidylinositol phosphatidylserine,other brain lipids.

Packaging

Sealed ampule.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers
Low C, et al.
Biophysical Journal, 95(9), 4315-4323 (2008)
Matthew J Buccilli et al.
Cells, 8(7) (2019-07-25)
Copines make up a family of calcium-dependent, phospholipid-binding proteins found in numerous eukaryotic organisms. Copine proteins consist of two C2 domains at the N-terminus followed by an A domain similar to the von Willebrand A domain found in integrins. We
Qing Lu et al.
Molecular biology of the cell, 22(22), 4268-4278 (2011-10-04)
Myosin X (MyoX) is an unconventional myosin that is known to induce the formation and elongation of filopodia in many cell types. MyoX-induced filopodial induction requires the three PH domains in its tail region, although with unknown underlying molecular mechanisms.
Cholesterol and Fat Metabolism in Alzheimer?s Disease
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders, 161-193 (2017)
Measurement of phosphoinositides in the zebrafish Danio rerio
Jones DR, et al.
Nature Protocols, 8(6), 1058-1058 (2013)

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