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Merck
CN

B1502

Brain Extract from bovine brain

Type I, Folch Fraction I

Synonym(s):

Brain Extract from Bovine

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352211
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biological source

bovine brain

Quality Level

type

Type I

form

powder

lipid type

phosphoglycerides

storage temp.

−20°C

General description

Brain extract has lipids, especially polyunsaturated fatty acids (PUFAs) at high level. Extract from substantia niagra and the striatum has high amount of iron.

Application

Brain Extract from bovine brain has been used:
  • to prepare small unilamellar vesicles
  • in lipid binding assay
  • to aid the recovery of phosphoinositides and also to terminate the reaction in phosphatidylinositol 5-phosphate (PtdIns5P) and PtdIns4P assay
  • in liposome and protein self-aggregation assays

Biochem/physiol Actions

Brain lipids are involved in cellular signal transduction, membrane organization, trafficking protein modification, interactions and energy storage.

Packaging

Sealed ampule.

Other Notes

Contains phosphatidylinositol phosphatidylserine,other brain lipids.


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers
Low C, et al.
Biophysical Journal, 95(9), 4315-4323 (2008)
Richard J Chi et al.
The Journal of cell biology, 204(5), 793-806 (2014-02-26)
Retromer is an endosomal sorting device that orchestrates capture and packaging of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs). We report that fission of retromer SNX-BAR-coated tubules from yeast endosomes is promoted by Vps1, a
Ina Ammendrup-Johnsen et al.
Biochemistry, 51(2), 586-596 (2011-12-02)
PICK1 (protein interacting with C kinase 1) contains an N-terminal protein binding PDZ domain and a C-terminal lipid binding BAR domain. PICK1 plays a key role in several physiological processes, including synaptic plasticity. However, little is known about the cellular



Global Trade Item Number

SKUGTIN
B1502-1G04061826656310
B1502-25MG04061832793467
B1502-100MG04061832793450