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B161

B-HT 933 dihydrochloride

Name: B-HT 933 dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride, Azepexole dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₅N₃O · 2HCl

CAS Number:

36067-72-8

Molecular Weight:

254.16

UNSPSC Code:

12352200

PubChem Substance ID:

24277762

MDL number:

MFCD01529923

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assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

H₂O: >20 mg/mL

SMILES string

Cl.Cl.CCN1CCc2nc(N)oc2CC1

InChI

1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7;;/h2-6H2,1H3,(H2,10,11);2*1H

InChI key

HBLPYIOKPJVFQW-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Selective α₂-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm.

G Lembo et al.

The Journal of clinical investigation, 100(8), 2007-2014 (1997-10-23)

We explored in 51 normal subjects, distributed in various series of experiments, whether endothelium nitric oxide may play a role in insulin modulation of alpha2- and beta-adrenergic- evoked vascular responses. In particular, we examined the forearm blood flow response (FBF

Characterization of alpha-adrenoceptor activity in the preterm piglet mesentery.

T V Hoang et al.

Journal of pediatric surgery, 31(12), 1659-1662 (1996-12-01)

To characterize neonatal mesenteric alpha-adrenoceptor populations, an extracorporeal perfusion circuit was established to control intestinal blood flow in prematurely delivered (by cesarean section at 90% of gestational age) piglets. Activation of alpha 1-adrenoceptors was documented by observing dose-dependent increases in

Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors.

Enrique F Castillo et al.

Fundamental & clinical pharmacology, 20(4), 339-349 (2006-07-27)

In rat aorta, the presence of functional alpha(2)-adrenoceptors (alpha(2)-AR) was investigated in ring preparations preconstricted with alpha(1)-adrenergic and non- alpha(1)-adrenergic agonists. Particularly, the hypothetical interference of alpha(2)-AR agonists with alpha(1)-AR-mediated vasoconstriction was evaluated. Relaxant and contractile responses to alpha(2)-AR agonists

Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats.

Luis E Cobos-Puc et al.

European journal of pharmacology, 616(1-3), 175-182 (2009-06-17)

This study analysed the inhibition produced by the agonists moxonidine (imidazoline I(1) receptors>alpha(2)-adrenoceptors) and agmatine (endogenous ligand of imidazoline I(1)/I(2) receptors), using B-HT 933 (6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride; alpha(2)-adrenoceptors) for comparison, on the rat cardioaccelerator sympathetic outflow. Male Wistar rats were pithed

α-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg.

David M Keller et al.

The Journal of physiology, 588(Pt 19), 3799-3808 (2010-08-10)

This study tested the hypothesis that passive leg heating attenuates α-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF

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