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B2133

N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride

Name: N-Benzoyl-Pro-Phe-Arg-<I>p</I>-nitroanilide hydrochloride
Brand: SIGMA

protease substrate, chromogenic, ≥97% (HPLC), powder

Synonym(s):

Bz-Pro-Phe-Arg-p-nitroanilide hydrochloride, Bz-Pro-Phe-Arg-pNA hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₃₃H₃₈N₈O₆ · HCl

CAS Number:

59188-28-2

Molecular Weight:

679.17

UNSPSC Code:

12352204

PubChem Substance ID:

24891630

NACRES:

NA.32

MDL number:

MFCD00039010

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Product Name

N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride, protease substrate

Quality Level

200

assay

≥97% (HPLC)

form

powder

solubility

methanol: 25 mg/mL

storage temp.

−20°C

SMILES string

Cl.NC(=N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)c3ccccc3)C(=O)Nc4ccc(cc4)N(=O)=O

InChI

1S/C33H38N8O6.ClH/c34-33(35)36-19-7-13-26(29(42)37-24-15-17-25(18-16-24)41(46)47)38-30(43)27(21-22-9-3-1-4-10-22)39-31(44)28-14-8-20-40(28)32(45)23-11-5-2-6-12-23;/h1-6,9-12,15-18,26-28H,7-8,13-14,19-21H2,(H,37,42)(H,38,43)(H,39,44)(H4,34,35,36);1H

InChI key

OGYWLWIIQPDFPW-UHFFFAOYSA-N

General description

A chromogenic substrate for Agkistrodon contortrix thrombin-like enzyme and plasma kallikrein.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000511455

0000511454

0000486957

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AM1, a glycoprotein from the submandibular glands of the mouse, has esterolytic and amidolytic activities.

A V Nieuw Amerongen et al.

Biochimica et biophysica acta, 786(3), 245-251 (1984-05-17)

The previously isolated female submandibular glycoprotein AM1 ( Nieuw Amerongen , A.V., Vreugdenhil , A.P. and Roukema , P.A. (1977) Biochim. Biophys. Acta 495, 324-335) has been shown to have hydrolytic activity using N-alpha-benzoyl-L-arginine ethylester (BAEE) and ChromozymR PK as

[Determination of factor XII and plasma prekallikrein with chromozym PK].

J Stürzebecher et al.

Zeitschrift fur medizinische Laboratoriumsdiagnostik, 23(5), 306-311 (1982-10-01)

Determination of factor XII in plasma using the kallikrein substrate chromozym PK.

C Klessen et al.

Thrombosis research, 25(6), 501-505 (1982-03-15)

[Use of chromogenic substrates in the clarification of disorders in the early stages of blood coagulation].

G Vogel et al.

Folia haematologica (Leipzig, Germany : 1928), 109(1), 115-120 (1982-01-01)

The kallikrein specific chromogenic peptide substrates S-2302 (KABI) and Chromozym PK (Boehringer) were used in the first analysis of a familial defect in the early stage of clotting. Slight to extensive prolongation of the activated partial thromboplastin time was seen

Effect of Neurotropin on the activation of the plasma kallikrein-kinin system.

K Nishikawa et al.

Biochemical pharmacology, 43(6), 1361-1369 (1992-03-17)

Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade. Neurotropin is a biological material obtained from inflamed rabbit skin inoculated with vaccinia virus and is widely used

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Global Trade Item Number

SKU	GTIN
B2133-100MG	04061833426593
B2133-25MG	04061835511792
B2133-5MG	04061833426609

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