B2682
Boc-Asp(OMe)-fluoromethyl ketone
≥90% (TLC), solid
Synonym(s):
Boc-D-FMK
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About This Item
Empirical Formula (Hill Notation):
C11H18NO5F
CAS Number:
Molecular Weight:
263.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥90% (TLC)
Form:
solid
Quality Segment
assay
≥90% (TLC)
form
solid
solubility
DMF: soluble
storage temp.
−20°C
SMILES string
COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
InChI
1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChI key
MXOOUCRHWJYCAL-ZETCQYMHSA-N
Application
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
Biochem/physiol Actions
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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