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Merck
CN

B2938

BEPP monohydrochloride

≥98% (HPLC), PKR activator, powder

Synonym(s):

1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H23N3O2 HCl
CAS Number:
455311-98-5
Molecular Weight:
409.91
UNSPSC Code:
12352200
PubChem Substance ID:
329773209
NACRES:
NA.77
MDL number:
MFCD00964481

Key Documents

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Product Name

BEPP monohydrochloride, ≥98% (HPLC)

SMILES string

Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24

InChI key

KDMXJFUGIDGZQL-UHFFFAOYSA-N

InChI

1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator.
BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000390795
0000390796
0000390796
0000390795
049K4621V

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Ana-Belén Blázquez et al.
PLoS neglected tropical diseases, 15(1), e0009072-e0009072 (2021-01-26)
Usutu virus (USUV) is an African mosquito-borne flavivirus closely related to West Nile, Japanese encephalitis, Zika, and dengue viruses. USUV emerged in 1996 in Europe, where quickly spread across the continent causing a considerable number of bird deaths and varied

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