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B2938

BEPP monohydrochloride

Name: BEPP monohydrochloride
Brand: SIGMA

≥98% (HPLC), PKR activator, powder

Synonym(s):

1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₃N₃O₂HCl

CAS Number:

455311-98-5

Molecular Weight:

409.91

UNSPSC Code:

12352200

PubChem Substance ID:

329773209

NACRES:

NA.77

MDL number:

MFCD00964481

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Product Name

BEPP monohydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24

InChI

1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H

InChI key

KDMXJFUGIDGZQL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Relevance of oxidative stress in inhibition of eIF2 alpha phosphorylation and stress granules formation during Usutu virus infection.

Ana-Belén Blázquez et al.

PLoS neglected tropical diseases, 15(1), e0009072-e0009072 (2021-01-26)

Usutu virus (USUV) is an African mosquito-borne flavivirus closely related to West Nile, Japanese encephalitis, Zika, and dengue viruses. USUV emerged in 1996 in Europe, where quickly spread across the continent causing a considerable number of bird deaths and varied

Global Trade Item Number

SKU	GTIN
B2938-25MG	04061832269306
B2938-5MG	04061833217498