B3188
BYK204165
≥98% (HPLC)
Synonym(s):
4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C15H12N2O2
CAS Number:
Molecular Weight:
252.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
yellow
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Cn1cccc1\C=C2/C(=O)NC(=O)c3ccccc23
InChI
1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-
InChI key
BTYSIDSTHDDAJW-LCYFTJDESA-N
Gene Information
human ... PARP1(142)
mouse ... PARP1(11545)
rat ... PARP1(25591)
Biochem/physiol Actions
BYK204165 is a potent and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1). It is 100-fold selective for PARP-1 over PARP-2.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Ningbo Zheng et al.
Cancer cell, 40(9), 973-985 (2022-08-27)
Cytotoxicity of tumor-specific T cells requires tumor cell-to-T cell contact-dependent induction of classic tumor cell apoptosis and pyroptosis. However, this may not trigger sufficient primary responses of solid tumors to adoptive cell therapy or prevent tumor antigen escape-mediated acquired resistance. Here
Facundo H Prado Spalm et al.
Molecular neurobiology, 56(7), 4760-4777 (2018-11-06)
Ceramide (Cer) has a key role inducing cell death and has been proposed as a messenger in photoreceptor cell death in the retina. Here, we explored the pathways induced by C2-acetylsphingosine (C2-Cer), a cell-permeable Cer, to elicit photoreceptor death. Treating
Robin M Hallett et al.
Molecular oncology, 10(9), 1461-1472 (2016-09-08)
In the pediatric cancer neuroblastoma (NB), patients are stratified into low, intermediate or high-risk subsets based in part on MYCN amplification status. While MYCN amplification in general predicts unfavorable outcome, no clinical or genomic factors have been identified that predict
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B3188-25MG | 04061833217504 |
| B3188-5MG | 04061833217511 |