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Merck
CN

B3412

Berberine hemisulfate salt

≥95%

Synonym(s):

Natural Yellow 18

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About This Item

Linear Formula:
C20H18NO4 · 1/2SO4
CAS Number:
633-66-9
Molecular Weight:
384.39
UNSPSC Code:
12171500
NACRES:
NA.32
PubChem Substance ID:
24891718
MDL number:
MFCD00031743
Colour Index Number:
75160
Assay:
≥95%
Form:
powder
Solubility:
methanol: soluble

Key Documents

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Product Name

Berberine hemisulfate salt, ≥95%

InChI

1S/2C20H18NO4.H2O4S/c2*1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;1-5(2,3)4/h2*3-4,7-10H,5-6,11H2,1-2H3;(H2,1,2,3,4)/q2*+1;/p-2

SMILES string

[O-]S([O-])(=O)=O.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.COc6ccc7cc8-c9cc%10OCOc%10cc9CC[n+]8cc7c6OC

InChI key

OJVABJMSSDUECT-UHFFFAOYSA-L

assay

≥95%

form

powder

solubility

methanol: soluble

Quality Level

100

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Application

Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCS9870
MKCK2558
MKCG7480
MKCF1144
SLBD0359V

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Dong-Gu Kim et al.
Molecular medicine reports, 21(1), 258-266 (2019-11-21)
The major role of inner medullary collecting duct (IMCD) cells is to maintain water and sodium homeostasis. In addition to the major role, it also participates in the protection of renal and systemic inflammation. Although IMCD cells could take part

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