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Merck
CN

B3805

Anti-Bone Morphogenetic Protein 5 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-BMP-5

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD01864602
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (frozen sections)
neutralization
western blot
Species reactivity:
human
Citations:
3
Technique(s):
immunohistochemistry (frozen sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
Uniprot accession no.:
P22003

Key Documents

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Product Name

Anti-Bone Morphogenetic Protein 5 antibody produced in goat, affinity isolated antibody, lyophilized powder

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

immunohistochemistry (frozen sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL

UniProt accession no.

P22003

application(s)

research pathology

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BMP5(653)

Biochem/physiol Actions

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP5 is required for the development and fine tuning of the skeletal morphology.

Immunogen

recombinant human BMP-5, expressed in NSO cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCL6735
MKCL0665
SLBB5485
100K0040

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Steven Pregizer et al.
Cytokine & growth factor reviews, 20(5-6), 509-515 (2009-11-11)
Much evidence suggests that "developmental regulator" genes, like those encoding transcription factors and signaling molecules, are typically controlled by many modular, tissue-specific cis-regulatory elements that function during embryogenesis. These elements are often far from gene coding regions and promoters. Bone
Elina V García et al.
Theriogenology, 81(8), 1032-1041 (2014-03-04)
Bone morphogenetic proteins (BMPs) play a crucial role in mammalian reproduction, but little is known about their expression and function in the oviduct, where preimplantation events take place. In the present study, messenger RNA (mRNA) expression of BMPs was examined
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various

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