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B4056

Bisindolylmaleimide XI hydrochloride

≥98% (TLC), solid

Synonym(s):

Ro 32-0432

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About This Item

Empirical Formula (Hill Notation):
C28H28N4O2 · HCl
Molecular Weight:
489.01
NACRES:
NA.77
PubChem Substance ID:
329773227
UNSPSC Code:
12352111
MDL number:
MFCD01319127
Assay:
≥98% (TLC)
Form:
solid
Quality level:
200
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Quality Level

200

assay

≥98% (TLC)

form

solid

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

Cl.CN(C)CC1CCn2c(C1)cc3ccc(cc23)C4=C(C(=O)NC4=O)c5cn(C)c6ccccc56

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H

InChI key

WMVQGKBSNAIMHI-UHFFFAOYSA-N

Biochem/physiol Actions

Selective inhibitor of protein kinase C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCF8900
SLCF3522
SLCF1011
SLCF0323
SLCD9855

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Guillaume Robert et al.
PloS one, 4(11), e7889-e7889 (2009-11-20)
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia (B-CLL) was investigated in different
S Khom et al.
Science advances, 6(12), eaaz1050-eaaz1050 (2020-03-25)
Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its
Caline S Karam et al.
Journal of chemical neuroanatomy, 83-84, 91-98 (2017-06-03)
The dopamine transporter (DAT), which mediates the inactivation of released dopamine through its reuptake, is the primary molecular target for the actions of psychostimulants. An increasing number of studies support an essential role for phosphorylation of serines (Ser) in the
View All Related Papers

Global Trade Item Number

SKUGTIN
B4056-1MG04061826121559
B4056-5MG04061832444543