B4311
BF-170 hydrochloride
≥98% (HPLC), solid
Synonym(s):
2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C15H12N2 · HCl
CAS Number:
Molecular Weight:
256.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light, under inert gas
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, protect from light, under inert gas
color
orange
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2
InChI
1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
InChI key
UYYPMQOFLJHJAW-UHFFFAOYSA-N
Biochem/physiol Actions
BF-170 is a new probe for neurofibrillary tangles (tau fibrils) with greater binding affinity to tau than to Aβ fibrils.
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
Disclaimer
Product is air sensitive, store under inert gas.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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