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Merck
CN

B4311

BF-170 hydrochloride

≥98% (HPLC), solid

Synonym(s):

2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H12N2 · HCl
CAS Number:
22191-97-5
Molecular Weight:
256.73
NACRES:
NA.77
PubChem Substance ID:
24891766
UNSPSC Code:
12352200
MDL number:
MFCD08705340

Key Documents

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InChI key

UYYPMQOFLJHJAW-UHFFFAOYSA-N

SMILES string

Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2

InChI

1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light, under inert gas

color

orange

solubility

H2O: 10 mg/mL

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

BF-170 is a new probe for neurofibrillary tangles (tau fibrils) with greater binding affinity to tau than to Aβ fibrils.
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

Disclaimer

Product is air sensitive, store under inert gas.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
046K46021
046K4602

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