B4311
BF-170 hydrochloride
≥98% (HPLC), solid
Synonym(s):
2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C15H12N2 · HCl
CAS Number:
Molecular Weight:
256.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light, under inert gas
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, protect from light, under inert gas
color
orange
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2
InChI
1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
InChI key
UYYPMQOFLJHJAW-UHFFFAOYSA-N
Biochem/physiol Actions
BF-170 is a new probe for neurofibrillary tangles (tau fibrils) with greater binding affinity to tau than to Aβ fibrils.
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
Disclaimer
Product is air sensitive, store under inert gas.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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