Name: Bradykinin Fragment 1-8 acetate salt hydrate
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₄₄H₆₁N₁₁O₁₀ · xC₂H₄O₂ · yH₂O

Molecular Weight:

904.02 (anhydrous free base basis)

MDL number:

MFCD00236892

UNSPSC Code:

12352200

PubChem Substance ID:

24891773

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Assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01042

storage temp.

−20°C

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(Cc5ccccc5)C(O)=O

InChI

1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)

InChI key

VCEHWDBVPZFHAG-UHFFFAOYSA-N

Gene Information

human ... KNG1 (includes EG:3827)

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Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

General description

Bradykinin Fragment 1-8, also known as des-Arg9-bradykinin, is produced by the cleavage of bradykinin at 8-9 position by carboxypeptidase N.

Application

Bradykinin Fragment 1-8 acetate salt hydrate has been used as a Bradykinin 1 receptor (B1R) agonist to investigate the expression and the role of B1R, in mediating neuronal injury under the chemical neurotoxicity paradigm in PC12 cell lines. It has also been used as an analyte in nanostructure-initiator mass spectrometry and matrix-assisted laser desorption/ionization (MALDI).

Biochem/physiol Actions

Bradykinin Fragment 1-8 is a selective B1 bradykinin receptor agonist. It promotes the release of nitric oxide, prostacyclin, endothelium-derived hyperpolarizing factor in the endothelium. des-Arg9-bradykinin also promotes vasodilatation and increases blood flow in the peripheral circulation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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