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Merck
CN

B4560

6-Bnz-cAMP sodium salt

≥98% (HPLC)

Synonym(s):

N6-Benzoyladenosine-3′,5′-cyclic monophosphate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C17H15N5O7PNa
CAS Number:
30275-80-0
Molecular Weight:
455.29
NACRES:
NA.77
PubChem Substance ID:
24724421
UNSPSC Code:
12352200
MDL number:
MFCD01074967

Key Documents

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Product Name

6-Bnz-cAMP sodium salt, ≥98% (HPLC)

InChI

1S/C17H16N5O7P.Na/c23-12-13-10(6-27-30(25,26)29-13)28-17(12)22-8-20-11-14(18-7-19-15(11)22)21-16(24)9-4-2-1-3-5-9;/h1-5,7-8,10,12-13,17,23H,6H2,(H,25,26)(H,18,19,21,24);/q;+1/p-1/t10-,12-,13-,17-;/m1./s1

SMILES string

[Na+].O[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3cnc4c(NC(=O)c5ccccc5)ncnc34

InChI key

SPYGSKQRPXISIB-FKVBDRBCSA-M

assay

≥98% (HPLC)

form

powder

packaging

vial of 10 μmol

storage condition

desiccated

color

white

solubility

H2O: freely soluble

shipped in

dry ice

storage temp.

−70°C

Quality Level

100

Related Categories

Biochem/physiol Actions

6-Bnz-cAMP is a membrane permeable and selective cAMP-dependent protein kinase (PKA) activator. For preferential stimulation of cAK type I, a combination with the site B selective analog 8-HA-cAMP or 8-AHA-cAMP can be used.
6-Bnz-cAMP is a membrane-permeable and selective cAMP-dependent protein kinase (PKA) activator.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000117647
0000117647
0000122619
074M4701V
053M4705V

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H Kita et al.
Journal of immunology (Baltimore, Md. : 1950), 146(8), 2712-2718 (1991-04-15)
We have investigated the effects of cAMP on Ig-induced human eosinophil activation. Stimulation of human normodense eosinophils with IgG- or secretory IgA (sIgA)-coated Sepharose beads induced cellular degranulation, as measured by the release of the granule protein, eosinophil-derived neurotoxin (EDN).
R Bøe et al.
British journal of cancer, 72(5), 1151-1159 (1995-11-01)
8-Cl-cAMP and 8-NH2-cAMP induced MCF-7 cell death. The type(s) of cell death were studied in more detail and compared with the cell death type (apoptosis) induced by okadaic acid, an inhibitor of serine/threonine phosphatases. By morphological criteria dying cells showed
Kevin W-H Lo et al.
Journal of tissue engineering and regenerative medicine, 6(1), 40-48 (2011-02-12)
Osteoblastic differentiation is an important landmark for bone formation, bone repair and regeneration; however, it is a very complex process controlled by different signalling mechanisms. Several groups have reported that the cyclic adenosine monophosphate (cAMP) signalling system is responsible for
K E Fladmark et al.
Hepatology (Baltimore, Md.), 25(4), 847-855 (1997-04-01)
The hepatocytes in the mature normal liver are tightly coupled through gap junctions, except during compensatory hyperplasia (regeneration) after partial hepatectomy when the gap junctions become down-regulated. The significance of this down-regulation has been a long-standing enigma. The present study
A H Ree et al.
Clinical & experimental metastasis, 14(4), 381-388 (1996-09-01)
Regulation of two genes involved in tumor invasion, the matrix metalloproteinase (MMP)-1 and the tissue inhibitor of MMP (TIMP)-1, by activators of protein kinase C (PKC) or protein kinase A (PKA) was studied in MCF-7 mammary adenocarcinoma cells. The basal
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