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B4636

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin

Name: Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin
Brand: SIGMA

protein C substrate, ≥98% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₅₂N₈O₁₀

CAS Number:

73554-93-5

Molecular Weight:

732.82

UNSPSC Code:

12352204

PubChem Substance ID:

24891793

NACRES:

NA.32

MDL number:

MFCD00080226

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Properties

Product Name

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin, protein C substrate

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

ethanol: 2 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)OC(C)(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C34H52N8O10/c1-17(2)13-23(41-33(50)52-34(5,6)7)29(47)40-24(16-43)30(48)42-27(19(4)44)31(49)39-22(9-8-12-37-32(35)36)28(46)38-20-10-11-21-18(3)14-26(45)51-25(21)15-20/h10-11,14-15,17,19,22-24,27,43-44H,8-9,12-13,16H2,1-7H3,(H,38,46)(H,39,49)(H,40,47)(H,41,50)(H,42,48)(H4,35,36,37)

InChI key

ZJNWKMRGENOMCV-UHFFFAOYSA-N

Description

General description

A fluorogenic substrate for activated protein C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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A new fluorogenic peptide substrate for vitamin K-dependent blood coagulation factor, bovine protein C.

Y Ohno et al.

Journal of biochemistry, 90(5), 1387-1395 (1981-11-01)

Protein C is a precursor of plasma serine proteinases, and its active form inactivates specifically blood coagulation Factor V and Factor VIII. Since a specific and sensitive synthetic substrate for the activated protein C was not known, we studied its

Trypsin-like hatching protease from mouse embryos: evidence for the presence in culture medium and its enzymatic properties.

H Sawada et al.

The Journal of experimental zoology, 254(1), 83-87 (1990-04-01)

Enzymatic properties of a protease involved in hatching of mouse embryos were examined. A trypsin-like protease, which most efficiently hydrolyzed t-butoxycarbonyl-Leu-Ser-Thr-Arg-4-methylcoumaryl-7-amide, was demonstrated in culture medium of mouse hatching embryos. The enzyme was strongly inhibited by diisopropyl fluorophosphate, phenylmethanesulfonyl fluoride

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

Brian T O'Neill et al.

The Journal of clinical investigation, 126(9), 3433-3446 (2016-08-16)

Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the

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Global Trade Item Number

SKU	GTIN
B4636-5MG	04061832904221
B4636-1MG	04061826671191