B4752
5-Bromocytosine
Synonym(s):
4-Amino-5-bromo-2-hydroxypyrimidine
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About This Item
Empirical Formula (Hill Notation):
C4H4BrN3O
CAS Number:
Molecular Weight:
190.00
EC Number:
218-806-8
UNSPSC Code:
12352204
MDL number:
Beilstein/REAXYS Number:
127286
InChI
1S/C4H4BrN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChI key
QFVKLKDEXOWFSL-UHFFFAOYSA-N
SMILES string
NC1=NC(=O)NC=C1Br
mp
240-243 °C (dec.) (lit.)
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Kristin A Seiberling et al.
International forum of allergy & rhinology, 2(1), 80-84 (2012-02-09)
One theory for the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) involves aberration in the expression of genes that maintain the sinonasal innate immune system. We propose that the alteration in gene expression seen in CRSwNP is a result
M Ortiz-Lombardía et al.
Nature structural biology, 6(10), 913-917 (1999-10-03)
DNA recombination is a universal biological event responsible both for the generation of genetic diversity and for the maintenance of genome integrity. A four-way DNA junction, also termed Holliday junction, is the key intermediate in nearly all recombination processes. This
Rodrigo Varas et al.
Brain research, 1072(1), 72-78 (2006-01-13)
Petrosal ganglion neurons are depolarized and fire action potentials in response to acetylcholine and nicotine. However, little is known about the subtype(s) of nicotinic acetylcholine receptors involved, although alpha4 and alpha7 subunits have been identified in petrosal ganglion neurons. Cytisine
C M Nunn
Journal of biomolecular structure & dynamics, 14(1), 49-55 (1996-08-01)
The crystal structure of the DNA decamer d(AGGBrCATGCCT) has been determined to a resolution of 2.0 A and R factor of 19.6%. Crystals of d(AGGBrCATGCCT) were grown in the presence of cobalt hexammine but no cobalt hexammine ions are bound
L M Houlihan et al.
Journal of neurochemistry, 78(5), 1029-1043 (2001-09-13)
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisine (3,5-diBr-cy) on human (h) alpha7-, alpha4beta2- and alpha4beta4 nicotinic acetylcholine (nACh) receptors, expressed in Xenopus oocytes and cell lines, have been investigated. Cy and its bromo-isosteres fully inhibited binding of
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