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Merck
CN

B5063

BMS-193885

≥98% (HPLC)

Synonym(s):

1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-dimethyl ester-3,5-pyridinedicarboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C33H42N4O6
CAS Number:
186185-03-5
Molecular Weight:
590.71
NACRES:
NA.77
PubChem Substance ID:
329773248
UNSPSC Code:
12352200
MDL number:
MFCD16878998
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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InChI key

WMYSXJSJXZFODY-UHFFFAOYSA-N

SMILES string

COC(=O)C1=C(C)NC(C)=C(C1c2cccc(NC(=O)NCCCN3CCC(CC3)c4cccc(OC)c4)c2)C(=O)OC

InChI

1S/C33H42N4O6/c1-21-28(31(38)42-4)30(29(22(2)35-21)32(39)43-5)25-10-6-11-26(19-25)36-33(40)34-15-8-16-37-17-13-23(14-18-37)24-9-7-12-27(20-24)41-3/h6-7,9-12,19-20,23,30,35H,8,13-18H2,1-5H3,(H2,34,36,40)

assay

≥98% (HPLC)

form

powder

color

light yellow to yellow

solubility

DMSO: >10 mg/mL

originator

Bristol-Myers Squibb

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

BMS-193885 is a potent, selective Y1 antagonist that is active in both acute and chronic animal models of food intake.
BMS-193885 is a potent, selective Y1 antagonist that is active in both acute and chronic animal models of food intake. Although it is active in vivo, it is not orally bioavailable due to poor intestinal absorption, so it is not being pursued for pharmaceutical development. BMS-193885 has been used as a pre-clinical proof of concept tool for showing efficacy of Y1 antagonism in treating obesity.

Features and Benefits

This compound is featured on the Neuropeptide Y Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
020M4611V
020M4611

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Shiba Yousefvand et al.
Canadian journal of physiology and pharmacology, 96(12), 1301-1307 (2018-10-17)
Neuropeptide Y (NPY) plays a mediatory role in cerebral insulin function by maintaining energy balance. The current study was designed to determine the role of insulin in food intake and its interaction with NPY receptors in 8 experiments using broiler
David Acton et al.
Cell reports, 28(3), 625-639 (2019-07-18)
Acute itch can be generated by either chemical or mechanical stimuli, which activate separate pathways in the periphery and spinal cord. While substantial progress has been made in mapping the transmission pathway for chemical itch, the central pathway for mechanical

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