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B5264

Kanamycin B sulfate salt

Name: Kanamycin B sulfate salt
Brand: SIGMA

aminoglycoside antibiotic

Synonym(s):

Bekanamycin sulfate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₃₇N₅O₁₀ · xH₂SO₄

Molecular Weight:

483.51 (free base basis)

UNSPSC Code:

51281654

NACRES:

NA.85

PubChem Substance ID:

24891829

MDL number:

MFCD00078511

Beilstein/REAXYS Number:

5235274

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Quality Level

200

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O

InChI

1S/C18H37N5O10.H2O4S/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18;1-5(2,3)4/h4-18,24-29H,1-3,19-23H2;(H2,1,2,3,4)/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+;/m0./s1

InChI key

YGTPKDKJVZOVCO-KELBJJLKSA-N

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Related Categories

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

General description

Chemical structure: aminoglycoside

Application

Used as a selection agent for cells transformed with kanamycin B (neoR, kanR) resistance gene.

Biochem/physiol Actions

Kanamycin B is an aminoglycoside antibiotic that is the 2-amino,2-deoxy-analog of kanamycin A. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasm.

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Preparation Note

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000515505

0000419625

0000370417

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Characterization of Kanamycin-Resistant Cell Lines of Nicotiana tabacum.

L D Owens

Plant physiology, 67(6), 1166-1168 (1981-06-01)

Two kanamycin-resistant variants of Nicotiana tabacum were derived by culturing seedling leaf sections on a shoot-inducing medium containing kanamycin. The variants displayed a higher resistance to the structurally related antibiotic streptomycin than to kanamycin. The resistance phenotype was expressed when

New publication: HortScience. "Kanamycin Sensitivity of Mango Somatic Embryos."

Helena Mathews and Richard E. Litz

Hortscience: a Publication of the American Society For Horticultural Science Hortscience, 25, 965-966 (1990)

Cholic Acid-Peptide Conjugates as Potent Antimicrobials against Interkingdom Polymicrobial Biofilms.

Siddhi Gupta et al.

Antimicrobial agents and chemotherapy, 63(11) (2019-08-21)

Interkingdom polymicrobial biofilms formed by Gram-positive Staphylococcus aureus and Candida albicans pose serious threats of chronic systemic infections due to the absence of any common therapeutic target for their elimination. Herein, we present the structure-activity relationship (SAR) of membrane-targeting cholic

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.

Scott McAuley et al.

Cell chemical biology, 26(9), 1274-1282 (2019-07-08)

Common approaches to antibiotic discovery include small-molecule screens for growth inhibition in target pathogens and screens for inhibitors of purified enzymes. These approaches have a shared intent of seeking to directly target a vital Achilles heel in a pathogen of

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Kumar Sachin Singh et al.

Nature, 589(7843), 597-602 (2020-12-29)

Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, mycobacteria and apicomplexans2,3. Its

Global Trade Item Number

SKU	GTIN
B5264-1G	04061833433676
B5264-100MG	04061833433669
B5264-250MG	04061833433683

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