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Merck
CN

B5311

Biperiden hydrochloride

≥98% (HPLC), powder

Synonym(s):

1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl

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About This Item

Empirical Formula (Hill Notation):
C21H30ClNO
CAS Number:
1235-82-1
Molecular Weight:
347.92
PubChem Substance ID:
329773254
UNSPSC Code:
12352200
EC Number:
214-976-2

Key Documents

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Product Name

Biperiden hydrochloride, ≥98% (HPLC), powder

InChI key

RDNLAULGBSQZMP-UHFFFAOYSA-N

InChI

1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H

SMILES string

Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

originator

Abbott

Quality Level

100

Gene Information

human ... CHRM1(1128)

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Biochem/physiol Actions

Antiparkinsonian; non-selective muscarinic receptor antagonist.
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M4705V
037K47113
037K47112
037K47111
037K4711

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Anna C Ramos et al.
Behavioural brain research, 231(1), 213-216 (2012-04-04)
Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are
Laila Asth et al.
Brain research bulletin, 87(6), 526-533 (2012-03-08)
The elevated T-maze (ETM) is an apparatus derived from the elevated plus-maze test, which is used to evaluate anxiety. Because anxiety is a biasing factor in models of memory, this study proposed the ETM as a task for the simultaneous
W Sperling et al.
Medical hypotheses, 76(5), 720-722 (2011-03-04)
In a regions of interest analysis (ROI) of the most frequent psychiatric disorders (schizophrenia, depression, anxiety, addiction), we found the nucleus lentiformis to be the topographical brain region most frequently cited in connection with these disorders in a regions of
A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden.
Sakae Takahashi et al.
The Journal of neuropsychiatry and clinical neurosciences, 25(1), E28-E28 (2013-03-15)
[Current classifications of dystonies, treatment strategy].
Z A Zalialova
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(3), 85-89 (2013-04-25)
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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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