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B6311

BTO-1

Name: BTO-1
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

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About This Item

Empirical Formula (Hill Notation):

C₉H₄N₄O₄S

CAS Number:

40647-02-7

Molecular Weight:

264.22

NACRES:

NA.77

PubChem Substance ID:

329773275

UNSPSC Code:

12352200

MDL number:

MFCD11045282

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

tan

solubility

H₂O: <2 mL/mL, DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O

InChI

1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)

InChI key

FKRBAXZAJBBIAJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BTO-1 is a polo-like kinase (Plk) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.

Campbell McInnes et al.

Nature chemical biology, 2(11), 608-617 (2006-10-10)

Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

Keiko Yata et al.

Molecular cell, 45(3), 371-383 (2012-02-14)

Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.

Kristin P Leister et al.

Current chemical genomics, 5, 21-29 (2011-06-07)

Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for detecting TNF-α, enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, are not

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Global Trade Item Number

SKU	GTIN
B6311-25MG	04061832444581
B6311-5MG	04061832444598