Key Documents

View All Documentation

B7005

Betamethasone

Name: Betamethasone
Brand: SIGMA

synthetic (organic), ≥98%, corticosteroid, powder

Synonym(s):

9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₉FO₅

CAS Number:

378-44-9

Molecular Weight:

392.46

NACRES:

NA.77

PubChem Substance ID:

57653954

UNSPSC Code:

51111800

EC Number:

206-825-4

MDL number:

MFCD00062969

Assay:

≥98%

Form:

powder

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Betamethasone, ≥98%

biological source

synthetic (organic)

Quality Level

100

sterility

non-sterile

assay

≥98%

form

powder

mp

235-237 °C (lit.)

solubility

water: 0.063 g/L at 37 °C

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

UREBDLICKHMUKA-DVTGEIKXSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecules

Application

Betamethasone has been used as a corticosteroid (CORT) standard.

Biochem/physiol Actions

Betamethasone, an isomer of dexamethasone is also termed as 9α-fluoro-16β-methyl-11 β,17,21-trihydroxypregna-1,4-dien-3,20-dione or 9α-fluoro-16β-methylprednisolone (27.1.52). It can be used as an anti-itch agent and treating dermatitis and eczema.

pictograms

GHS08

signalword

Danger

hcodes

H360FD,H373

pcodes

P201 - P202 - P260 - P280 - P308 + P313 - P405

Hazard Classifications

Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Corticosteroids

Synthesis of Essential Drugs, 349-363 (2006)

A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs.

Munoz, P. et al.

Analytica Chimica Acta, 529(1), 137-144 (2005)

Glucocorticoid regulation of human pulmonary surfactant protein-B (SP-B) mRNA stability is independent of activated glucocorticoid receptor.

Ceá C Tillis et al.

American journal of physiology. Lung cellular and molecular physiology, 300(6), L940-L950 (2011-03-15)

Adequate expression of surfactant protein-B (SP-B) is critical in the function of pulmonary surfactant to reduce alveolar surface tension. Expression of SP-B mRNA is restricted to specific lung-airway epithelial cells, and human SP-B mRNA stability is increased in the presence

Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5).

Elizabeth V Asztalos et al.

JAMA pediatrics, 167(12), 1102-1110 (2013-10-16)

A single course of antenatal corticosteroid therapy is recommended for pregnant women at risk of preterm birth between 24 and 33 weeks' gestational age. However, 50% of women remain pregnant 7 to 14 days later, leading to the question of

A combination therapy protocol of plasmapheresis, intravenous immunoglobulins and betamethasone to treat anti-Ro/La-related congenital atrioventricular block. A case series and review of the literature.

Amelia Ruffatti et al.

Autoimmunity reviews, 12(7), 768-773 (2013-01-24)

The aim of this report was to evaluate the efficacy and safety of a combined treatment protocol used to treat 2nd and 3rd degree anti-Ro/La-related congenital atrioventricular block (CAVB). Six consecutive women diagnosed with 2nd degree (three cases) or 3rd

View All Related Papers

Global Trade Item Number

SKU	GTIN
B7005-100MG	04061835517695
B7005-500MG	04061835553938

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service