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Merck
CN

B7260

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride

protease substrate, ≥99% (TLC), powder

Synonym(s):

Bz-Arg-AMC hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H25N5O4 · HCl
CAS Number:
83701-04-6
Molecular Weight:
471.94
UNSPSC Code:
12352204
PubChem Substance ID:
24891979
NACRES:
NA.83
MDL number:
MFCD00039020

Key Documents

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Product Name

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride, protease substrate

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)c3ccccc3)ccc12

InChI

1S/C23H25N5O4.ClH/c1-14-12-20(29)32-19-13-16(9-10-17(14)19)27-22(31)18(8-5-11-26-23(24)25)28-21(30)15-6-3-2-4-7-15;/h2-4,6-7,9-10,12-13,18H,5,8,11H2,1H3,(H,27,31)(H,28,30)(H4,24,25,26);1H/t18-;/m0./s1

InChI key

XKAVYOJOHZLTDF-FERBBOLQSA-N

assay

≥99% (TLC)

form

powder

solubility

DMSO:methanol (1:1): 20 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Application

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a substrate for trypsin-like proteolysis of peptide in red blood cells
  • as a substrate for midgut proteases of Pieris brassicae
  • as a substrate in screening serine protease activity of venom

General description

A sensitive fluorogenic substrate for papain and trypsin.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ5437
BCCF4906
BCBP5436V
BCBG5111V
BCBD2059V

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Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros
Vaiyapuri S, et al.
Testing, 5(3), e9687-e9687 (2010)
Trypsin-like proteolytic contamination of commercially available psa purified from human seminal fluid
Manning ML, et al.
Prostate, 72(11), 1233-1238 (2012)
Kanaoka, Y., et al.
Chemical & Pharmaceutical Bulletin, 25, 3126-3126 (1977)
Rakesh Kumar et al.
Frontiers in physiology, 6, 95-95 (2015-04-16)
Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larvae of P. brassicae also feed prolifically on garden nasturtium (Tropaeolum majus L., of the family Tropaeolaceae). Proteolytic digestion was studied in larvae feeding
Carmen Navarro-Guillén et al.
PloS one, 16(4), e0248356-e0248356 (2021-04-10)
New and more efficient methods to sustainably intensify Aquaculture production are essential to attain the seafood demand for direct human consumption in the near future. Nutrition has been identified as one strategy of early exposure that might affect animal early
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