Skip to Content
Merck
CN

B7272

Sigma-Aldrich

4-Bromo-calcium Ionophore A23187

apoptosis inhibitor, powder

Synonym(s):

4-Bromo-A23187, 4-Bromo-calcimycin

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C29H36BrN3O6
CAS Number:
76455-48-6
Molecular Weight:
602.52
MDL number:
MFCD00077667
UNSPSC Code:
12352202
PubChem Substance ID:
24891982
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

4-Bromo-calcium Ionophore A23187, powder

form

powder

Quality Level

200

color

yellow

solubility

ethanol: 20 mg/mL
DMSO: soluble

storage temp.

2-8°C

SMILES string

CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

InChI

1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1

InChI key

LDXQFZZGVTWFCF-FHYGWRBKSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.

Biochem/physiol Actions

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.

Other Notes

Analog of calcium ionophore A23187

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000409156
0000362523
0000409156
0000362523
0000231253

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kinetics of endogenous CaMKII required for synaptic plasticity revealed by optogenetic kinase inhibitor.
Murakoshi H, et al.
Neuron, 94(1), 37-47 (2017)
Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.
Whyte MK, et al.
The Journal of Clinical Investigation, 92(1), 446-455 (1993)
Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons.
Kim HJ, et al.
Experimental & Molecular Medicine, 39(5), 574-574 (2007)
R Martínez-Zaguilán et al.
Journal of cellular physiology, 176(1), 196-205 (1998-06-09)
We investigated whether alterations in the mechanisms involved in intracellular pH (pHin) and intracellular calcium ([Ca2+]in) homeostasis are associated with the metastatic potential of poorly (A375P) and highly (C8161) metastatic human melanoma cells. We monitored pHin and [Ca2+]in simultaneously, using
G A Lnenicka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4966-4972 (1998-06-23)
In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2+ ionophore application, normally active tonic motor axons continue to grow, whereas
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service