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Merck
CN

B7652

Betamethasone 21-phosphate disodium

≥97%, glucocorticoid steroid, powder

Synonym(s):

Betamethasone disodium phosphate, Betamethasone sodium phosphate

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About This Item

Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
151-73-5
Molecular Weight:
516.40
EC Number:
205-797-0
MDL number:
MFCD00200361
UNSPSC Code:
12352200
PubChem Substance ID:
24892013
NACRES:
NA.77

Key Documents

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Product Name

Betamethasone 21-phosphate disodium, ≥97%

sterility

non-sterile

Quality Level

100

Assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

InChI key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

Gene Information

human ... NR3C1(2908)

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General description

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants

Biochem/physiol Actions

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H360FD,H373

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

Target Organs

Liver,Kidney,Endocrine system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7800
MKCQ4978
MKCK3324
MKBS9676V
SLBB0343V

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Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial
Dalziel SR, et al.
Lancet, 365(9474), 1856-1862 (2005)
Tsutomu Sakai et al.
Investigative ophthalmology & visual science, 52(3), 1516-1521 (2010-12-24)
The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. EAU was induced by
Masatomo Kato et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 27(4), 353-360 (2011-05-18)
Glucocorticoids exert their actions via the glucocorticoid receptor through at least 2 intracellular mechanisms, known as transrepression and transactivation. It has been hypothesized that transrepression is the basis of their anti-inflammatory effects, whereas transactivation has been assumed to cause their
Istemi Yucel et al.
Archives of orthopaedic and trauma surgery, 129(5), 695-701 (2008-10-08)
The aim of the study was to compare the efficacies of steroid injections guided by scintigraphy, ultrasonography, and palpation in plantar fasciitis. A total of 35 heels of 27 patients were randomly assigned to three steroid injection groups: palpation-guided (pg)
Alan H Jobe et al.
American journal of obstetrics and gynecology, 201(6), 611-611 (2009-10-06)
We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically. Ewes with singleton pregnancies were treated with single doses of 0.25-mg/kg or 0.5-mg/kg betamethasone acetate, 4 doses of 0.25-mg/kg betamethasone
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