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About This Item
Empirical Formula (Hill Notation):
C25H37N3O5
CAS Number:
Molecular Weight:
459.58
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)
SMILES string
OC(CNN1C(CCCCCCC(O)=O)C(=O)N(Cc2ccccc2)C1=O)C3CCCCC3
InChI key
YZJVWSKJHGEIBL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
film
color
colorless
solubility
DMSO: 5 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
BW A868C is a potent, selective DP prostanoid receptor antagonist.
Features and Benefits
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Andrea Ebersberger et al.
Pain, 152(5), 1114-1126 (2011-02-25)
Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which augments these currents. Prostaglandin D(2) (PGD(2)) is
Maxime A Gallant et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 20(4), 672-681 (2005-03-15)
Human osteoblasts produce PGD(2), which acts on the DP receptor to decrease osteoprotegerin production and on the CRTH2 receptor to decrease RANKL expression and to induce osteoblast chemotaxis. These results indicate that activation of CRTH2 may lead to an anabolic
Hui Zhao et al.
Prostaglandins & other lipid mediators, 88(3-4), 68-72 (2008-11-15)
We found that prostaglandin (PG) D(2), the most abundant PG produced in the central nervous system (CNS), exhibited anxiolytic-like activity at a dose of 10-100pmol/mouse after intracerebroventricular (i.c.v.) administration in the elevated plus-maze test in mice. A DP(1) receptor-selective agonist
T Minami et al.
The Journal of pharmacology and experimental therapeutics, 278(3), 1146-1152 (1996-09-01)
We previously reported that intrathecal administration of prostaglandin (PG) D2 and PGE2 to conscious mice induced hyperalgesia (assessed by a hot-plate test) and that intrathecal administration of PGE2 and PGF2 alpha induced allodynia, a state of discomfort and pain evoked
G Monneret et al.
Blood, 98(6), 1942-1948 (2001-09-06)
Prostaglandin D2 (PGD2) is released following exposure of asthmatics to allergen and acts via the adenylyl cyclase-coupled receptor for PGD2 (DP receptor). In this study, it is reported that human eosinophils possess this receptor, which would be expected to inhibit
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