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Merck
CN

B9180

BW A868C

≥98% (HPLC)

Synonym(s):

3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid

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About This Item

Empirical Formula (Hill Notation):
C25H37N3O5
CAS Number:
118675-50-6
Molecular Weight:
459.58
NACRES:
NA.77
PubChem Substance ID:
329773313
UNSPSC Code:
12352200
MDL number:
MFCD00877696

Key Documents

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InChI

1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)

SMILES string

OC(CNN1C(CCCCCCC(O)=O)C(=O)N(Cc2ccccc2)C1=O)C3CCCCC3

InChI key

YZJVWSKJHGEIBL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

film

color

colorless

solubility

DMSO: 5 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

BW A868C is a potent, selective DP prostanoid receptor antagonist.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
114M4733V
059K4718
056K47051
056K4705
104K47021

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L Oliveira et al.
British journal of pharmacology, 129(3), 509-514 (2000-03-11)
1. Cumulative concentration-effect curves for the selective prostanoid TP receptor agonist U46619 and six isoprostanes were constructed in the human isolated umbilical artery. 2. All compounds except 8-iso-PGF3 alpha produced concentration-dependent contractions. The contractile response to the isoprostanes increased with
Hui Zhao et al.
Peptides, 29(3), 345-349 (2008-01-09)
Met-Arg-Trp (MRW) has been isolated as an inhibitor for angiotensin I-converting enzyme (ACE) from a pepsin-pancreatin digest of spinach ribulose bisphosphate carboxylase/oxygenase (Rubisco) (IC(50)=0.6 microM). It has been reported that hypotensive activity of ACE-inhibitory peptides derived from food proteins are
Andrea Ebersberger et al.
Pain, 152(5), 1114-1126 (2011-02-25)
Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which augments these currents. Prostaglandin D(2) (PGD(2)) is
Hui Zhao et al.
Prostaglandins & other lipid mediators, 88(3-4), 68-72 (2008-11-15)
We found that prostaglandin (PG) D(2), the most abundant PG produced in the central nervous system (CNS), exhibited anxiolytic-like activity at a dose of 10-100pmol/mouse after intracerebroventricular (i.c.v.) administration in the elevated plus-maze test in mice. A DP(1) receptor-selective agonist
Md Ashequr Rahman et al.
European journal of pharmacology, 567(3), 245-251 (2007-06-05)
The present study was undertaken to investigate the involvement of chemical mediators in nasal allergic responses using histidine decarboxylase knockout (HDC-KO) mice. An allergic rhinitis model was developed in HDC-KO and wild-type mice by the intraperitoneal injection of ovalbumin, aluminum
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