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Merck
CN

B9688

Pizotifen

≥98% (HPLC)

Synonym(s):

Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C19H21NS
CAS Number:
15574-96-6
Molecular Weight:
295.44
NACRES:
NA.77
PubChem Substance ID:
329773323
UNSPSC Code:
12352200
EC Number:
239-632-9
MDL number:
MFCD00864192

Key Documents

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Product Name

Pizotifen, ≥98% (HPLC)

InChI key

FIADGNVRKBPQEU-UHFFFAOYSA-N

InChI

1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

SMILES string

CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24

assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥8 mg/mL

originator

Novartis

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

Pizotifen is a Serotonin antagonist used for prophylaxis of migraine
Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000499335
0000499335
0000416709
0000416710
0000416710

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Richard Young et al.
Pharmacology, biochemistry, and behavior, 82(2), 404-410 (2005-10-29)
MDMA (N-methyl-3,4-methylenedioxyamphetamine) produces a discriminative stimulus (DS) effect in animals, but attempts to completely block this action with selective neurotransmitter antagonists have not been very successful. Biochemically, MDMA can increase synaptic levels of serotonin, dopamine, and norepinephrine that, conceivably, might
Abdeslam Chagraoui et al.
Psychopharmacology, 170(1), 17-22 (2003-08-09)
Agomelatine, an antidepressant with melatonin agonist and 5-HT(2C) antagonist properties, as well as two of its main metabolites, S 21517 (N-[2-(7-hydroxy-1-naphtyl)ethyl]acetamide) and S21540 (N-[2-(3-hydroxy-7-methoxynaphtalen-1-yl)ethyl]acetamide), have been assessed in vitro on pig choroid plexus preparations to determine their affinities for 5-HT(2C)
C E Serna-Jiménez et al.
Biomedical chromatography : BMC, 26(6), 769-774 (2011-10-18)
Pizotifen malate is an antihistamine and serotonin inhibitor used in the preventive treatment of migraine and eating disorders. A simple, rapid, accurate and precise high-performance liquid chromatography (HPLC) method involving ultraviolet detection was validated for the quantitative analysis of pizotifen
G L Briars et al.
Archives of disease in childhood, 93(7), 590-593 (2008-04-03)
To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifen Retrospective case note review West Suffolk Hospital between 1999 and 2003 PATIENTS: 405 clinic attendances of 121 children receiving pizotifen treatment Rates of change
Tomasz Huć et al.
Pharmacological research, 130, 172-179 (2017-12-31)
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and
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