B9688
Pizotifen
≥98% (HPLC)
Synonym(s):
Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine
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About This Item
Empirical Formula (Hill Notation):
C19H21NS
CAS Number:
Molecular Weight:
295.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
239-632-9
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ≥8 mg/mL
originator
Novartis
storage temp.
room temp
SMILES string
CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24
InChI
1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
InChI key
FIADGNVRKBPQEU-UHFFFAOYSA-N
Biochem/physiol Actions
Pizotifen is a Serotonin antagonist used for prophylaxis of migraine
Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
We offer many products related to serotonin receptors for your research needs.
我们提供许多血清素受体相关产品，满足您的各类研究需求。
Do pizotifen or propranolol reduce the frequency of migraine headache?
N Barnes et al.
Archives of disease in childhood, 89(7), 684-685 (2004-06-24)
Joy A Weydert et al.
Pediatrics, 111(1), e1-11 (2003-01-02)
To conduct a systematic review of evaluated treatments for recurrent abdominal pain (RAP) in children. Online bibliographic databases were searched for the terms "recurrent abdominal pain," "functional abdominal pain," "children," or "alternative therapies" in articles classified as randomized controlled trials.
Abdeslam Chagraoui et al.
Psychopharmacology, 170(1), 17-22 (2003-08-09)
Agomelatine, an antidepressant with melatonin agonist and 5-HT(2C) antagonist properties, as well as two of its main metabolites, S 21517 (N-[2-(7-hydroxy-1-naphtyl)ethyl]acetamide) and S21540 (N-[2-(3-hydroxy-7-methoxynaphtalen-1-yl)ethyl]acetamide), have been assessed in vitro on pig choroid plexus preparations to determine their affinities for 5-HT(2C)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B9688-50MG | 04061832079448 |
| B9688-10MG | 04061832079431 |