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Merck
CN

B9806

Heparin−biotin sodium salt

≥97%

Synonym(s):

Heparin-Biotin Conjugate

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About This Item

UNSPSC Code:
12352201
eCl@ss:
34058011
NACRES:
NA.25
MDL number:
MFCD03457057

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Product Name

Heparin−biotin sodium salt, ≥97%

conjugate

biotin conjugate

assay

≥97%

form

solid

mol wt

~15000 Da

solubility

H2O: soluble 1 mg/mL, clear, colorless

storage temp.

2-8°C

Quality Level

200

Related Categories

Application

Heparin-biotin is used transfection research for the development of self-assembled terplexes such as polyamidoamine dendrimer and DNA (PAMAM/DNA) heparin-biotin terplexes for targeted gene delivery with improved transfection. The terplexes may be used in immobilizing proteins such as lactoferrin and lysozyme and nucleic acids.

Other Notes

Biotin conjugated to heparin from porcine intestinal mucosa

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9119
MKCZ0610
MKCW6865
MKCT7646
MKCT6676

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Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
S Zou et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 889-895 (1992-12-01)
1. Binding of biotin-heparin to immobilized lactoferrin and lysozyme was optimum at pH 6.0, 100 mM NaCl. Complex interactions between NaCl and CaCl2 concentrations were observed for heparin binding to both proteins. 2. The metal ions Cu2+, Zn2+, Fe2+ and
Xue-Qing Zhang et al.
Bioconjugate chemistry, 18(6), 2068-2076 (2007-09-13)
We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated.
Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
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