Skip to Content
Merck
CN

BM0002

Sigma-Aldrich

Omapatrilat

≥98% (HPLC)

Synonym(s):

(4S,7S,10aS)-Octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, BMS-186716

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C19H24N2O4S2
CAS Number:
167305-00-2
Molecular Weight:
408.53
MDL number:
MFCD00935634
UNSPSC Code:
12352200
PubChem Substance ID:
329774350
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -70 to -85°, c = 0.5 in DMF

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

S[C@H](C(N[C@@H]1C(N([C@H](C(O)=O)CCC2)[C@@]2([H])SCC1)=O)=O)CC3=CC=CC=C3

InChI

1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-8-4-7-14(19(24)25)21(16)18(13)23/h1-3,5-6,13-16,26H,4,7-11H2,(H,20,22)(H,24,25)/t13-,14-,15-,16-/m0/s1

InChI key

LVRLSYPNFFBYCZ-VGWMRTNUSA-N

General description

Omapatrilat is a vasopeptidase dual NEP (neutral endopeptidase)/ACE (angiotensin-converting enzyme) inhibitor. It consists of a mercaptoacyl derivative of a bicyclic thazepinone dipeptide. It is used to treat heart failure.

Biochem/physiol Actions

Omapatrilat is a vasopeptidase inhibitor, a dual metalloprotease inhibitor of neutral endopeptidase (NEP, neprilysin) and angiotensin converting enzyme (ACE).
Omapatrilat is a vasopeptidase inhibitor, a dual metalloprotease inhibitor of neutral endopeptidase (NEP, neprilysin) and angiotensin converting enzyme (ACE). Omapatrilat is a highly potent antihypertensive agent, but was not approved to treat hypertension because of increased incidence of angioedema.

Features and Benefits

Omapatrilat is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
125M4741V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The role of nitric oxide in heart failure (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service